European cities face major social challenges due to global geopolitical, economic, climate, and other changes; this puts urban areas under a lot of stress to provide environments that support Public Health (PH) and well-being (WB). The conventional approach to urban and revitalization planning is based mostly on profit criteria with routine methodologies, often lacking advanced integrated methods and concepts with emphasis on PH, WB, cultural, economic, and societal aspects. Hence, the needs of local communities are not recognized or neglected and cities end up with costly investments that are not embraced by local communities and therefore lack sustainability. To address these challenges, euPOLIS NBS-based Urban Planning methodologies enriched with cultural and societal aspects offer the synergy of a people-centered approach with significant environmental and economic benefits of Blue Green Solutions.