The EPIPELAGIC project is a Bilateral and Multilateral Cooperation project between Greece and China focused on monitoring coastal areas. The project’s main goal is to address and mitigate the effects of climate change and natural disasters by providing methodologies and tools that use time series of Earth Observation satellite data in combination with other auxiliary data and field measurements. The main objective is to create an electronic platform and a decision support platform to monitor and evaluate significant changes that can be associated with natural and anthropogenic hazards, including land use change, shoreline changes over time, soil erosion, ground deformation, and sea and groundwater level monitoring. EPIPELAGIC aims at demonstrating the capabilities of satellite synergistic observations analysis to evaluate suitable indicators. The research activities to be carried out will provide sustainable support to local culture, society, economy, and environment in both countries.